Pepsi & Shirlie are an English pop duo group formed in London in 1985. who released two albums, All Right Now in 1987 and Change in 1991. Their debut single "Heartache" reached No. 2 in the UK Singles Chart.

The act comprised Helen "Pepsi" DeMacque (born 10 December 1958, Paddington, London) and Shirlie Holliman (born 18 April 1962, Watford, Hertfordshire), who had been Wham! backing vocalists.

On Monday 5 January 1987, they released their debut single "Heartache", which was produced by Phil Fearon and Tambi Fernando and  mixed by Stock Aitken Waterman and Pete Hammond. The song reached No. 2 in the UK Singles Chart. "Heartache" also peaked at number two on the American dance charts.